Uncertain on what is a “cannabinoid”? These are compounds released by cannabis that interact with a network of receptors. Known as the endocannabinoid system in our body. CBGA is formed in the trichomes of the plant to perform a defensive role for cannabis. And causes targeted plant cell necrosis for natural leaf pruning to allow the plant to optimize energy. Directed towards the flower.
How do we get CBGA?
CBGA is the cannabis flower’s foundational compound. You might really think of CBGA as the “granddaddy” of cannabinoids. But why? Since the three main cannabinoid lines are at the top of the cascade reaction that generates CBGA:
- THCA (tetrahydrocannabinolic acid)
- CBDA (cannabidiolic acid)
- CBCA (cannabichromenic acid)
These finally become, respectively, THC, CBD, or CBC. CBGA may also convert to CBG, but CBGA ultimately converts into either THC or CBD in most strains.
CBGA The Discovery
For over 50 years, scientists have known about CBG (cannabigerol). The first to isolate the cannabinoid were Israeli researchers. And 30 years later, Japanese researchers were the first to announce that its precursor was CBGA. Despite its long history, to date, limited research has been carried out on CBGA.
Most of the CBGA studies have concentrated on the sustainable development of THCA for research and pharmaceutical applications. Specifically, this study looked at the mechanism for translating CBGA into THCA. In a genus of yeast known as Pichia pastoris. Which is commonly used for recombinant DNA proteins, researchers have shown a reliable way of replicating the cannabinoid.
Research teams have also conducted computer modeling to maximize development. And a California research team published their work on full cannabinoid synthesis from yeast derivatives, like CBGA, in 2019.
In the past, since it rarely occurs in large amount. CBGA has been seen as a minor player in the cannabis plant. (usually, if present at all, it is in quantities of less than 1 percent ). However, as expert growers are beginning to breed strains with high levels of this unusual cannabinoid, there is great enthusiasm.
CBGA’s future Medical Benefits
Although there is very little medical research on CBGA yet carried out. Early studies offer some clues down the road about its possible applications.
CBGA can help diabetic patients battle some of the complications and comorbidities of the condition, such as cardiovascular disease. CBGA was tested in vitro and found to substantially inhibit the aldose reductase enzyme. A major contributor to the heart and other problems caused by oxidative stress. The results of the CBGA tests were, as predicted, highly dose dependent.
For many patients, synthetic inhibitor drugs have serious side effects, so a plant-derived drug is a promising prospect.
Another research team discovered that patients with other metabolic disorders may also be assisted by CBGA. A 2019 silico (computer simulation) study was conducted to examine the role of CBGA. In activating the receptor activated peroxisome proliferator (PPARs)
People develop diseases such as diabetes and high levels of cholesterol or triglycerides when PPARs do not work properly (dyslipidemia).. Promoting lipid metabolism and thus reducing excess accumulation of lipid. In animal and human trials, the research needs to be replicated.
Disease of Huntington’s
One of the neurodegenerative disorders that researchers are eyeing for CBGA therapeutic potential is Huntington’s Disease. A progressive brain condition that causes loss of memory, movement and emotional thought. CBGA was shown to protect neurons in mice with Huntington’s disease in a recent study in 2015.
Cancer of the Colon
Finally, CBGA, the third most common cancer and the fourth leading cause of cancer-related death. May one day prove crucial for patients. With colorectal cancer. Researchers looked at the cytotoxic effects of cannabis-extracted CBGA and found that not only did CBGA kill colon cancer cells. But it increased the death of early cancer cells and halted the cycle of cancer cells.
The researchers were encouraged that this could effectively target not only colon cancer cells. But could also prevent polyp growth and proliferation, though more research is certainly required. These polyps, left untreated, develop into carcinomas.
Conclusion on CBGA
Regarding all aspects of CBGA consumption, there is a huge lack of research. While some anecdotal reports talk about juicing and ingesting CBGA from cannabis. It is often advised to consult your doctor until your own hands are checked.